Registration Dossier
Registration Dossier
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EC number: 800-149-9 | CAS number: 1410795-90-2
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Diethylene glycol diformate, EC10 (3 h): 580 mg/L based on the respiration rate of activated sludge microorganisms (OECD 209).
This result is used for the assessment of the substance 1,2,3-propanetriol, mono- and diformates in a read-across approach (for details and justification please refer to the read-across report).
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 430 mg/L
Additional information
One experimental study investigating the inhibition of the respiration of diethylene glycol diformate (CAS 120570-77-6) to activated sludge microorganisms is available (Roulstone, 2012). The study was conducted according to OECD 209 under GLP conditions using activated sludge from a sewage treatment plant treating predominantly domestic sewage. Five concentrations up to 1000 mg/L (nominal) were tested. After 3 h contact time diethylene glycol diformate resulted in an EC10 of 580 mg/L based on the respiration rate.
The result for diethylene glycol diformate is used for the assessment of the substance 1,2,3-propanetriol, mono- and diformates in a read-across approach (for details and justification please refer to the read-across report).
The EC10 of 580 mg/L diethylene glycol diformate (M= 162.14 g/mole) corresponds to ca. 430-530 mg/L 1,2,3-propanetriol, mono- and diformates (M = 120.1-148.11 g/mole).
This result is supported by a second study: the toxicity of ethylene diformate (CAS 629-15-2) to microorganisms was investigated in a biodegradation study according to OECD 301B under GLP conditions (Roulstone, 2013). The toxicity control available in this test contained activated sludge of a predominantly domestic sewage, reference substance (sodium benzoate) and the test substance at a concentration of 28.4 mg/L. The toxicity control attained 81% degradation after 14 d of incubation. Since more than 35% degradation was observed in the toxicity control, the substance is with high probability not toxic to aquatic microorganisms. The test item concentration in the toxicity control of 28.4 mg/L can be used as NOEC value for the toxicity to aquatic microorganisms. Thus, a NOEC (14 d) of ≥ 28.4 mg/L resulted for ethylene glycol diformate (M = 118.1 g/mole), which corresponds to a NOEC in the range of
28.9-35.6 mg/L 1,2,3-propanetriol, mono- and diformates (M = 120.1-148.11 g/mole).Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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