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EC number: 203-892-1 | CAS number: 111-65-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Irritating to the skin.
Not irritating to the eyes.
Key value for chemical safety assessment
Additional information
There are no skin or eye irritation data available on octane. However, there are reliable data available for another category member. Thus, read-across was conducted based on a category-approach.
In a primary skin irritation study (Chevron Phillips Chemicals, 1982), iso-octane was applied to the intact skin of rabbits for 24 hours. At 72 hours post application, very slight erythema (grade 1) were observed in 3 of 6 rabbits. No other dermal effects were noted in the study. Based on persistent irritation at premature study termination (reversibility was not seen 72 hours after application), iso-octane was considered to be skin irritating.
The eye irritation potential of iso-octane was determined by instillation of 0.1 mL of the test material into the conjunctival sac of rabbits with subsequent washing (Chevron Phillips Chemicals, 1982). Conjunctival redness (grade 2) was noted in 4 of 6 rabbits at 1 hour post instillation and persisted in one rabbit to 24 hours. The redness reversed by 48 hours. No corneal opacity, iritis, conjunctival chemosis, or discharge was noted in any of the 6 rabbits.
In another primary eye irritation study of Chevron Phillips Chemicals (1982), the treated eyes of all animals remained unwashed. Conjunctival redness (grade 2) was noted in 3 of 6 rabbits at 1 hour post instillation and persisted in two rabbits to 24 hours. All redness reversed by 48 hours. No corneal opacity, iritis, conjunctival chemosis, or discharge was noted in any of the 6 rabbits.
Justification for classification or non-classification
According to Annex 1 to Directive 67/548/EEC, octane is classified as skin irritant.
DSD: R38
CLP: Skin Irritation Category 2
Based on read-across from a structurally related substance within a category approach, the available data on the eye irritating potential of octane are conclusive but not sufficient for classification.
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