Registration Dossier
Registration Dossier
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EC number: 210-743-4 | CAS number: 622-58-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Remarks:
- other: Code of Federal Regulations, Title 16, Section 1500.42
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable and well documented
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- 100 µl m-tolylisocyanate was applied into the conjunctival sac of the right eye of 6 rabbits. Reading was carried out 24, 48 and 72 h after start of application of the test substance.
- GLP compliance:
- no
Test material
- Reference substance name:
- m-tolyl isocyanate
- EC Number:
- 210-676-0
- EC Name:
- m-tolyl isocyanate
- Cas Number:
- 621-29-4
- Molecular formula:
- C8H7NO
- IUPAC Name:
- 1-isocyanato-3-methylbenzene
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 8 days (eye was not washed after application of the test substance)
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 6 animals
Results and discussion
In vivo
Results
- Irritation parameter:
- other: primary irritation index
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 54.1
- Max. score:
- 110
- Reversibility:
- not fully reversible within: 8 d
- Other effects:
- Eight days after application of the test substance, a slow repair of the cornea damage was observed. The condition of the chemosis and the inflamation of the conjunctiva were unchanged, no repair was visible.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information
- Executive summary:
100 µl m-tolylisocyanate was applied into the conjunctival sac of the right eye of 6 rabbits. Reading was carried out 24, 48 and 72 h after start of application of the test substance.
Eight days after application of the test substance, a slow repair of the corneal damage was observed. The condition of the chemosis and the inflamation of the conjunctiva were unchanged, no repair was visible.
A primary irritation index of 54.1 was found. The test-substance m-tolylisocyanate is highly irritating (R 41) to the eyes.
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