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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

No skin irritation/corrosion and eye irritation studies for p-tolylisocyanate are available.

Key value for chemical safety assessment

Additional information

No skin irritation/corrosion and eye irritation studies for p-tolylisocyanate are available.

m-tolylisocyanate (structural isomere) is regarded as a structural analogue or surrogate for p-tolylisocyanate and a read-across from this supporting substance is justified due to the close stuctural similarity to the target compound.

In 2 valid studies m-tolyl isocyanate was found corrosive to the skin.

In 2 valid studies on eye irritation, m-tolyl isocyanate was found highly irritating.

Justification for classification or non-classification

Due to the results of the key study of m-tolyl isocyanate for skin irritation/corrosion R34 is justified

Due to the severe effects of m-tolyl isocyanate on the eye R41 is adequate

In addition, respiration irritational effects were reported in the acute inhalation study (Pauluhn, 1988) for m-tolylisocyanate. Therefore R 37 is applicable