Registration Dossier
Registration Dossier
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EC number: 210-743-4 | CAS number: 622-58-2
Endpoint summary
Administrative data
Description of key information
Only acute toxicity studies from a secondary source (oral, inhalation, other routes) for p-tolylisocyanate are available. In the acute oral toxicity study a LD50 of ca. 1600 to 3200 mg/kg bw was found.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 1 600 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 33 mg/m³ air
Additional information
Only acute toxicity studies from a secondary source (oral, inhalation, other routes) for p-tolylisocyanate are available. In the acute oral toxicity study a LD50 of ca. 1600 to 3200 mg/kg bw was found.
m-tolylisocyanate (structural isomere) is regarded as a structural analogue or surrogate for p-tolylisocyanate and a read-across from this supporting substance is justified due to the close stuctural similarity to the target compound.
m-tolylisocyanate:
In 2 reliable oral toxicity studies a LD50 of 2926 mg/kg bw and 3191 mg/kg bw on male and female rats were found
In a guideline study according OECD 403 for male rats a LC50 = 33 mg/m³ air and for female rats a LC50 = 30 mg/m³ air (analytical vapour concentration) was found.
For acute dermal toxicty no data were available.
p-tolylisocyanate:
In a not assignable study a LD50 = ca. 1600 - 3200 mg/kg bw was determined. In a not assignable study a LC100 < 4.74 mg/l air bw was found. The results correlate with the findings for m-tolyl isocyanate for acute oral toxicity or are are not in contrast to the results of the inhalation study for m-tolyl isocyanate.
Justification for classification or non-classification
For the acute oral toxicity a classification as Xn, R 22 (GHS: Acute Tox. 4, H 302) is justified.
For the acute inhalation toxicity T+, R26 is justified as a result of the LC50 = 30 mg/m³ air
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