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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Specific investigations: other studies

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Administrative data

Endpoint:
mechanistic studies
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: special investigation

Data source

Reference
Reference Type:
publication
Title:
Experimental study on Skin sensitization with tolylene diisocyanate
Author:
Ohsawa T, Ishizu S
Year:
1983
Bibliographic source:
Tokyo Joshi Ika Daigaku Zasshi 53, 273-277, 1983

Materials and methods

Principles of method if other than guideline:
The present study compared the skin-sensitizing ability of three (o-, m-, p-) tolylisocyanate (TI) isomers with TDI in mice, in order to investigate whether the 2 isocyanate groups are both necessary or one of them plays the dominant part in skin sensitization with TDI.
GLP compliance:
not specified
Type of method:
in vivo
Endpoint addressed:
skin sensitisation

Test material

Constituent 1
Chemical structure
Reference substance name:
o-tolyl isocyanate
EC Number:
210-389-0
EC Name:
o-tolyl isocyanate
Cas Number:
614-68-6
Molecular formula:
C8H7NO
IUPAC Name:
1-isocyanato-2-methylbenzene
Constituent 2
Chemical structure
Reference substance name:
m-tolyl isocyanate
EC Number:
210-676-0
EC Name:
m-tolyl isocyanate
Cas Number:
621-29-4
Molecular formula:
C8H7NO
IUPAC Name:
1-isocyanato-3-methylbenzene
Constituent 3
Chemical structure
Reference substance name:
p-tolyl isocyanate
EC Number:
210-743-4
EC Name:
p-tolyl isocyanate
Cas Number:
622-58-2
Molecular formula:
C8H7NO
IUPAC Name:
1-isocyanato-4-methylbenzene

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
other: no data
Vehicle:
other: no data
Duration of treatment / exposure:
no data
Frequency of treatment:
no data
Post exposure period:
no data
No. of animals per sex per dose:
no data

Results and discussion

Details on results:
All 3 TI isomers resulted to have skin-sensitising ability, though a weaker degree compared to that of TDI. However, there was no significant difference among the 3 isomers.

Any other information on results incl. tables

All 3 TI isomers resulted to have skin-sensitising ability, though a weaker degree compared to that of TDI. However, there was no significant difference among the 3 isomers.

Applicant's summary and conclusion

Executive summary:

All 3 TI isomers resulted to have skin-sensitising ability, though a weaker degree compared to that of TDI. However, there was no significant difference among the 3 isomers.

These results suggest that the presence of one isocyanate group is enough to cause skin sensitisation, despite of its position on the benzene ring.