Registration Dossier

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Basic data given

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1957
Report Date:
1957

Materials and methods

Principles of method if other than guideline:
other: BASF-Test
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit

Administration / exposure

Route of administration:
intravenous

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD100
Effect level:
ca. 93 mg/kg bw
Based on:
test mat.
Mortality:
Single i.v. application of the amine and the neutralized amine at a dose of 93 mg/kg bw led 100% lethality within several minutes. Single i.v. application of the amine at a dose of about 70 mg/kg bw led to lethality in some of the animals within several minutes. After single i.v. application ot the neutralized amine at a dose of about 46 mg/kg bw and of the neutralized hydrochloride at a dose of about 70 mg/kg bw the animals survived.

Applicant's summary and conclusion