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EC number: 200-261-2 | CAS number: 56-18-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
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- Additional physico-chemical information
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- Endpoint summary
- Stability
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- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
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- Biological effects monitoring
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- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
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- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3,3'-iminodi(propylamine)
- EC Number:
- 200-261-2
- EC Name:
- 3,3'-iminodi(propylamine)
- Cas Number:
- 56-18-8
- Molecular formula:
- C6H17N3
- IUPAC Name:
- bis(3-aminopropyl)amine
- Details on test material:
- - Name of test material (as cited in study report): Dipropylentriamin
- Analytical purity: 99%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Firma WIGA (Sulzfeld)
- Weight at study initiation: 185 ± 15 gram
- Diet: Tieren Herilan MRH (Firma H . EGGERSMANN KG, Rinteln/Weser), ad libitum
- Water: ad libitum
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- other: ethanol
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: a constant quantity was ensured by a continuous infusion pump (UNITA I, B. BROWN, Melsungen) and by means of compressed air in a two-material nozzle which produces aerosols.
- Source and rate of air: 1000 L/h
TEST ATMOSPHERE
- Brief description of analytical method used: Gaschromatograph HP 5040 A with a 2 m glass colum (2 mm i.d.), with a Carbowax 20 M separation phase and Supelcoport 80/100 mesh carrier. The oventemperature is 200 °C, the detector (FID) and injector temperature are 280 °C, the corriergas flow is 20.4 ml/in, the hydrogen flow rate is 30 ml/min and the air flow is 255 ml/min. The retetion time of the internal standard (C17KW) is 2.66 min and the retetion time of the sample is 5.06.
- Samples taken from breathing zone: yes
CLASS METHOD
- Rationale for the selection of the starting concentration: First orientating dose was: 2.5 mg/L (analytical determined) - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- Nominal concentrations: 0.015, 0.037, 0.063, 0.47, 0.931, 4.66 and 8.37 mg/L
Measured concentrations: 0.014, 0.027, 0.055, 0.235, 0.606, 1.3 and 2.0 mg/L - No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of weighing: before dosing, after 7 days and after 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight. - Statistics:
- Probability analyses from D.J. Finney ( D.J. Finney; Probitanalysis 1971, Seite 1-150). The LC50 was calculated with 95% probability.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- ca. 0.03 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 0.04 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- 0.03 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- 0.014 mg/L: none of the animals died after 14 days
0.027 mg/L: 3/10 males and 6/10 females after 14 days
0.055 mg/L: 8/10 males and 9/10 females after 14 days
0.235 mg/L and up: all animals died after 14 days - Clinical signs:
- other: Red eye and nasal secretion, dyspnoea, imbalanced and insecure walk, crouched position, apathy, bad general condition, ragged and clotty fur, 2/10 females suffered hair loss, shaking, delayed pain reaction, cyanosis.
- Body weight:
- 0.014 mg/L: normal body weight gain
0.027 mg/L: reduced body weight gain
0.055 mg/L: body weight loss - Gross pathology:
- Diseased animals:
Acute dilatation of the heart, acute congested hyperemia, notable wet fleshy, edematous and diffuse redness of the lungs(bloody, lung hemorrhages), peripheral lobular pattern in the liver.
Euthanized animals:
0.014 mg/L: no abnormal findings
0.027 mg/L: carnification of the lungs
0.055 mg/L: strong weight loss, areas of carnification in the lungs
Applicant's summary and conclusion
- Executive summary:
In an inhalation toxicity study, comparable to OECD 403, Sprague-Dawley rats (10/sex/dose) were exposed (nose/head only) for 4 hours to 0.014 to 2.0 mg dipropylenetriamine aerosols/L air followed by an 14 day observation period. The LC50 was ca. 0.03 mg/L air.
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