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EC number: 200-261-2 | CAS number: 56-18-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- BASF-Test: The study was conducted according to an internal BASF method which in principle is comparable to the OECD Guideline 401.
A test group consisting of 5 animals/sex was treated by single gavage application with an aqueous solution of the test substance. The animals were observed for mortality and for clinical symptoms of toxicity. At the end of the observation period of 14 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy. - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3,3'-iminodi(propylamine)
- EC Number:
- 200-261-2
- EC Name:
- 3,3'-iminodi(propylamine)
- Cas Number:
- 56-18-8
- Molecular formula:
- C6H17N3
- IUPAC Name:
- bis(3-aminopropyl)amine
- Details on test material:
- - Analytical purity: 99%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Firma WIGA, Sulzfeld
- Weight at study initiation: male animals; 188g, female animals; 159 g
- Fasting period before study: 16 hours
- Diet: MRH-Kraftfutter from the Firma H . EGGERSMANN (Rinteln/Weser), ad libitum
- Water: ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 4.64, 5.62, 6.81, 8.25, 10, 12.1 and 14.7 %
MAXIMUM DOSE VOLUME APPLIED: 1470 mg/kg - Doses:
- 464, 562, 681, 825, 1000, 1210 and 1470 mg/kg
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: 1, 24, 48 hours, 7 and 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 700 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 640 - 770
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 670 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 580 - 750
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 740 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 650 - 860
- Mortality:
- 464 mg/kg: 0/10 males and 1/10 females after 14 days
562 mg/kg: 5/10 males and 3/10 females after 14 days
681 mg/kg: 4/10 males and 4/10 females after 14 days
825 mg/kg: 8/10 males and 4/10 females after 14 days
1000 mg/kg: 9/10 males and 8/10 females after 14 days
1210 and 1470 mg/kg: all animals died after 14 days - Clinical signs:
- other: Dyspnoea, apathy, agitation, aggressive, lateral and dorsal position, staggering, atony, paresis, trembling, spastic movement, rolling cramps, fever convulsions, diarrhea, salivation, diminished general state.
- Gross pathology:
- Acute dilation of the heart, acute congestion hyperemia, diffuse reddening of glands mucosa of proventriculus, atonic intestine, diarrhea in intestine, sporadic diffuse reddening of the mucosa of the intestine, brightening of the kidneys.
Euthanasied animals
Slight brightening of the kidneys with gridlike pattern.
Applicant's summary and conclusion
- Executive summary:
In an oral toxicity study, comparable to OECD 401, dipropylenetriamine was administered to Sprague-Dawley rats (10animals/sex/dose) at 464 to 1470 mg/kg in single dosages (gavage) followed by a 14-day observation period.The LD50 was ca. 700 mg/kg bw.
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