Registration Dossier

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
high hazard (no threshold derived)
Most sensitive endpoint:
genetic toxicity
Acute/short term exposure
Hazard assessment conclusion:
high hazard (no threshold derived)
Most sensitive endpoint:
genetic toxicity
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
high hazard (no threshold derived)
Most sensitive endpoint:
irritation (respiratory tract)
Acute/short term exposure
Hazard assessment conclusion:
high hazard (no threshold derived)
Most sensitive endpoint:
irritation (respiratory tract)
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
high hazard (no threshold derived)
Most sensitive endpoint:
genetic toxicity
Acute/short term exposure
Hazard assessment conclusion:
high hazard (no threshold derived)
Most sensitive endpoint:
genetic toxicity
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
high hazard (no threshold derived)
Most sensitive endpoint:
skin irritation/corrosion
Acute/short term exposure
Hazard assessment conclusion:
high hazard (no threshold derived)
Most sensitive endpoint:
skin irritation/corrosion

Workers - Hazard for the eyes

Local effects

Hazard assessment conclusion:
high hazard (no threshold derived)

Additional information - workers

3,3'-iminodi(propylamine) is classified for germ cell mutagenicity (cat. 2). The available data do not provide a dose response relationship. According to "ECHA Guidance on IR/CSR Chapter R.8" (ECHA-2010-G-19-EN, Nov. 2012), when no threshold can be derived, a qualitative approach to assessing and controlling the risks is necessary. Based on the substance's classification it is allocated to the high hazard band and appropriate Risk Management Measures and Operational Conditions are used (acc. to ECHA Guidance on IR/CSR Part E, Nov. 2012). 3,3'-iminodi(propylamine) is exclusively used in industrial settings. Procedural and control technologies are used to minimise residual emissions/exposure as well as qualitative risk considerations: operational and technical conditions and measures affecting and controlling workers exposure, such as local exhaust ventilation as well as personal protective equipment, such as goggles, chemically resistant gloves, and respiratory protection where potential exposure may occur.   

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
high hazard (no threshold derived)
Most sensitive endpoint:
genetic toxicity
Acute/short term exposure
Hazard assessment conclusion:
high hazard (no threshold derived)
Most sensitive endpoint:
genetic toxicity
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
high hazard (no threshold derived)
Most sensitive endpoint:
genetic toxicity
Acute/short term exposure
Hazard assessment conclusion:
high hazard (no threshold derived)
Most sensitive endpoint:
genetic toxicity
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
high hazard (no threshold derived)
Most sensitive endpoint:
genetic toxicity
DNEL related information
Justification:
T
Acute/short term exposure
Hazard assessment conclusion:
high hazard (no threshold derived)
Most sensitive endpoint:
genetic toxicity
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
high hazard (no threshold derived)
Most sensitive endpoint:
skin irritation/corrosion
Acute/short term exposure
Hazard assessment conclusion:
high hazard (no threshold derived)
Most sensitive endpoint:
skin irritation/corrosion

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
high hazard (no threshold derived)
Most sensitive endpoint:
genetic toxicity
Acute/short term exposure
Hazard assessment conclusion:
high hazard (no threshold derived)
Most sensitive endpoint:
genetic toxicity
DNEL related information

General Population - Hazard for the eyes

Local effects

Hazard assessment conclusion:
high hazard (no threshold derived)

Additional information - General Population

3,3'-iminodi(propylamine) is classified for germ cell mutagenicity (cat. 2). The available data do not provide a dose response relationship. According to "ECHA Guidance on IR/CSR Chapter R.8" (ECHA-2010-G-19-EN, Nov. 2012), when no threshold can be derived, a qualitative approach to assessing and controlling the risks is necessary. Based on the substance's classification it is allocated to the high hazard band and appropriate Risk Management Measures and Operational Conditions are needed (acc. to ECHA Guidance on IR/CSR Part E, Nov. 2012). 3,3'-iminodi(propylamine) is not used in consumer products. Furthermore, based on existing data a quantitative risk assessment related to potential exposure of the general population via secondary poisoning is not triggered.