Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

From the information available on the bio-availability, metabolism and excretion of chlorocresol in guinea pigs and rats, it can be concluded that the bio-accumulation potential of the chemical is expected to be low. This is due to the fact that majority of the administered 3-methyl 4-chlorophenol (54-95%) was excreted out of the living system of Wistar Rats through the urine within 24 hours.

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential

Additional information

Cresols can penetrate deeply into tissues that are exposed. After Cresols are absorbed, most of the chemical is metabolized by the liver and either the metabolites or the unchanged chemical are excreted by the kidney with trace amounts excreted via the lungs. In vivo, the Cresol isomers are conjugated and excreted as glucuronides and sulfates. Significant amounts of Cresols are secreted in the bile and undergo enterohepatic recirculation. The kidney is the main route for removing cresols. There are no reports that suggest bio-accumulation of cresol within the living system.