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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Description of key information

The Lethal concentration (LC50) value of chlorocresol to aquatic invertebrate daphnia magna in 48 hrs study on the basis of mortality effect was observed at dose concentration of 2 mg/l. But the BCF value of chlorocresol reported was not >= 2000 as well as the substance was found to be rapidly degradable. Thus according to CLP criteria of aquatic classification it is concluded that the substance chlorocresol is not toxic to aquatic invertebrate daphnia magna.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
2 mg/L

Additional information

Based on the various studies available with Klimish rating 2 and for target chemical CAS NO 59-50-7 The results is summarized as follows

 

Sr.No

Endpoint

Effect values

Basis for effects

Duration

Species

Remarks

1

LC50

2 mg/l

mortality

48 hrs

Daphnia magna

Data from publication for target chemical

2

LC50

1.5 mg/L.

 

mortality

48 hrs

Daphnia magna

Data from publication for target chemical

3

LC50

2 mg/L.

 

mortality

48 hrs

Daphnia magna

Data from study report for target chemical

4

LC50

2.3 mg/L.

 

mortality

48 hrs

Daphnia magna

Data from study report for target chemical

 

By applying weight of evidence approach to the studies summarized in the above table it can be observed that LC50 value is expected to be in range of 1.5 to 2.3 mg/l in a 48 hrs study on the basis of mortality effect. But the BCF value of chlorocresol reported was not >= 2000 as well as the substance was found to be rapidly degradable. Thus according to CLP criteria of aquatic classification it is concluded that the substance chlorocresol is not toxic to aquatic invertebrate daphnia magna. However, since this chemical has a harmonized classification as "Aquatic acute 1 " category, for the pupose of chemical safety assessment, this classification shall be considered