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EC number: 230-813-8 | CAS number: 7328-22-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 08.08.2005-15.11.2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- GLP.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 13th April 2004
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Vehicle:
- no
- Details on test solutions:
- A stock solution with 400 mg Butyldiglycol methacrylate per litre dilution water was prepared.
• Each test concentration was prepared in a volumetrie flask (500 mL) by dilution of appropriate amounts of the stock solution.
• All solutions were stirred continuously for homogeneity.
Concentration of test
substance
[mg/L] to be tested Amount of stock solution in mL pipetted ad 500mL
1 1.25
2 2.5
4 5
8 10
16 20
32 40
64 80
128 160 - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain: Straus
- Source: Landesamt für Wasser-und Abfallwirtschaft, Düsseldorf, Germany
- Age: not older than 24 hours
-Number of animals: 30
- Food type: Desmodesmus subspicatus
- Amount: During holding daphnia were fed daily with an appropriate amount of algae which could roughly consumed per day.
-Breeding
Organisms were held in beakers with a nominal capacity of 2000 mL which were filled with approx. 1400 mL dilution water. 15 - 20 adult
organisms were held in one beaker in order to get a high reproduction rate and viable newborns.
Breeding beakers were kept at an additional artificial light-dark cycle of 16 to 8 hours in a temperature controlled laboratory at 20 ± 2°C. Breeding
water was renewed three times a week (Monday, Tuesday, Friday). - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- none
- Hardness:
- Total hardness:2.574 mmol/l
Carbonate hardness: 0.7 up to 0.9 mmol/l - Test temperature:
- 21.7 -22.0 °C
- pH:
- 8.32-8.45
- Dissolved oxygen:
- Oxygen saturation: 62-67 %
- Nominal and measured concentrations:
- The nominal concentrations did not deviate from the analytically determined concentrations of the test substance.
The analytically determined amount of the test substance after 0, 24 and 48 hours was 86 % to 99 % of the nominal concentrations.
The analytical determination showed that there was no loss of test substance during the course of the test (48 hours). - Details on test conditions:
- Five test beakers were filled with approximately 30 mL of each test concentration and the dilution water (control). For each test concentration and the control one additional beaker was filled for measurement of temperature, oxygen saturation and pH - value.
Temperature and pH value were measured concurrently by pH meter .
•Thirty daphnia, divided into six repetitions were used for each test concentration and the control, respectively, (five per vessel). One of these replicates only served for measurement of temperature, oxygen and pH-value (swimming inability data from these replicates were excluded from evaluation).
• The daphnia were placed in the beakers by means of a small sieve made of stainless steel in order to minimise the transfer of dilution water.
• One and two days after exposure daphnia were observed for immobilisation.
• Daphnia which were unable to swim after gentle agitation of the beaker were considered to be immobile.
• Temperature, oxygen saturation and pH-value were measured daily in each tested concentration and the control.
• The following four additional samples in 400 mL beakers were prepared for anaIytical determinations by the test site AQura GmbH, Marl, Germany. Approximately 300 mL each of the control (dilution water) and the concentrations 1, 16, 128 mg Butyldiglycol methacrylate /L dilution water were
filled into the beakers (to be stored under the same conditions as the test vessels) and an amount of 30 mL was daily (0, 24, 48 h) filled into 50 mL
glass flasks, closed with screw caps and stored in a freezer (approx. -20°C). At the end of the experiment the samples were sent to the test site. For
transport the samples were shipped on ice.
30 ml of the stock solution (400 mg Butyldiglycol methacrylate /L dilution water) were prepared Iikewise on day 0. - Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 94.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% confidence limits: 68 to 158 mg/l
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- >= 128 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- The results of this study show that the test substance Butyldiglycol methacrylate induced swimming inability to the exposed Daphnia within 48 hours.
The ECo, EC5Q and EC100 values after 2 days of exposure were 8 mg/L, 94.7 mg/L and >128 mg/L, respectively.
There were no immobilised Daphnia in the control group. - Validity criteria fulfilled:
- yes
- Conclusions:
- EC50 (48 h) Daphnia magna of Butyldigylcol methacrylate is 94.7 mg/l
- Executive summary:
The 48–hr-acute toxicity of Butyldiglycol methacrylate to Daphnia magna was studied under static conditions acc. OECD Guideline 202. Daphnids were exposed to nominal concentration of 1; 2; 4; 8; 16; 32; 64; and 128 mg /L for 48 hr. Immobilization effects were observed daily. The 48– hour EC50was 94.7 mg /L. This study is classified as acceptable and satisfies the guideline requirements for an acute toxicity study with freshwater invertebrates.
Results Synopsis
Daphnia magna, static, 48 h:
EC50: 94.7 mg /L 95% C.I. : 68 to 158 mg./L
EC0: 8.mg /L
Endpoint effected: mobility
NOTE: Any of data in this dataset are disseminated by the European Union on a right-to-know basis and this is not a publication in the same sense as a book or an article in a journal. The right of ownership in any part of this information is reserved by the data owner(s). The use of this information for any other, e.g. commercial purpose is strictly reserved to the data owners and those persons or legal entities having paid the respective access fee for the intended purpose.
Reference
Vessel No. |
Nominal conc (mg test substance/l) |
Immobilized daphnia per test vessel |
|||||||||
|
|
1d |
2d |
||||||||
1-5 |
Control |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
6-10 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
11-15 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
16-20 |
4 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
21-25 |
8 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
26-30 |
16 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
2 |
1 |
31-35 |
32 |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
2 |
1 |
36-40 |
64 |
0 |
0 |
0 |
0 |
0 |
0 |
3 |
1 |
1 |
1 |
41-45 |
128 |
0 |
0 |
0 |
0 |
0 |
5 |
2 |
3 |
2 |
5 |
Nominal conc. (mg test substance/l) |
Number immobilized daphnia |
Cumulative frequency (%) |
||
1d |
2d |
1d |
2d |
|
Control |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
2 |
0 |
0 |
0 |
0 |
4 |
0 |
0 |
0 |
0 |
8 |
0 |
0 |
0 |
0 |
16 |
0 |
3 |
0 |
12 |
32 |
0 |
4 |
0 |
16 |
64 |
0 |
6 |
0 |
24 |
128 |
0 |
17 |
0 |
68 |
Description of key information
EC50 Daphnia magna (48h) = 94.7 mg/l
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- 94.7 mg/L
Additional information
One short term study to aquatic invertebrates with BDGMA is available acc. OECD 202 under static conditions which is considered to be reliable without restriction (Klimisch score 1). Daphnids were exposed at nominal concentrations of 1; 2; 4; 8; 16; 32; 64; and 128 mg /L for 48 hr.
The 48– hour EC50 was 94.7 mg /L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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