Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 239-743-2 | CAS number: 15667-63-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: no full report, One animal only, but due to severe damage sufficient information for evaluation of the irritating properties.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- 1-cyanoallyl acetate
- EC Number:
- 239-743-2
- EC Name:
- 1-cyanoallyl acetate
- Cas Number:
- 15667-63-7
- Molecular formula:
- C6H7NO2
- IUPAC Name:
- 1-cyanoprop-2-en-1-yl acetate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 2x0.5 mL (corresponds to 444 mg/kg bw)
- Duration of treatment / exposure:
- 40 min
- Observation period:
- 40 min
- Number of animals:
- 1
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 40 min after application the animal died
- Max. score:
- 4
- Reversibility:
- other: not determinable
- Remarks on result:
- not determinable
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 40 min after application the animal died
- Max. score:
- 4
- Reversibility:
- other: not determinable
- Remarks on result:
- not determinable
- Irritant / corrosive response data:
- skin effects could not be determined, because 10 minutes after application strong toxic response (clonic convulsion, decrease of muscel tone, breath depression) was observed and after 40 min death occured.
Any other information on results incl. tables
Skin effects could not be determined, because 10 minutes after application strong toxic response (clonic convulsion, decrease of muscel tone, breath depression) was observed and after 40 min death occured.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Remarks:
- Criteria used for interpretation of results: expert judgment
- Conclusions:
- No skin irritating properties could be determined due to its toxic potential after dermal application. However, in an acute dermal toxicity study (85-005-DKT), redness and crusts of the skin were observed 3-40 min post application. Therefore, the substance should be classified as Corrosive Cat. 1B according to Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
