Registration Dossier

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: no full report, One animal only, but due to severe damage sufficient information for evaluation of the irritating properties.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982
Report Date:
1982

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied: 2x0.5 mL (corresponds to 444 mg/kg bw)


Duration of treatment / exposure:
40 min
Observation period:
40 min
Number of animals:
1

Results and discussion

In vivo

Irritant / corrosive response data:
skin effects could not be determined, because 10 minutes after application strong toxic response (clonic convulsion, decrease of muscel tone, breath depression) was observed and after 40 min death occured.

Any other information on results incl. tables

skin effects could not be determined, because 10 minutes after application strong toxic response (clonic convulsion, decrease of muscel tone, breath depression) was observed and after 40 min death occured.

Applicant's summary and conclusion

Interpretation of results:
other: toxic via dermal penetration
Remarks:
Criteria used for interpretation of results: expert judgment
Conclusions:
No skin irritating properties could be determined due to its toxic potential after dermal application.