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Short-term toxicity to fish

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Reference
Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods
Qualifier:
according to guideline
Guideline:
other: DIN 38412
Principles of method if other than guideline:
Method: DIN 38412
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
yes
Details on test solutions:
560 mg of Acroleincyanhydrin-o-acetat was weighed and dissolved in 10 ml dimethylsulphoxide (DMSO), this solution was further diluted with DMSO. 1 ml of the concentrated solutions were added to 10 l of dilution water to prepare the test solution.
Test organisms (species):
Leuciscus idus
Details on test organisms:
Fishes were obtained from a commercial hatchery. Average length and weight were 6.1 +/-0.3 cm and 1.9 +/- 0.3 g.
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Test temperature:
20 +/- 1°C
pH:
7.2 - 8.0
Dissolved oxygen:
> 6.1 mg/l
Nominal and measured concentrations:
nominal: 0.32, 0.56, 1, 1.8, 3.2, 4.2 and 5.6 mg/l
Reference substance (positive control):
no
Duration:
48 h
Dose descriptor:
NOEC
Effect conc.:
0.32 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
behaviour
Duration:
48 h
Dose descriptor:
LC0
Effect conc.:
0.56 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
0.75 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Remarks on result:
other: (0.56-1.0)
Duration:
48 h
Dose descriptor:
LC100
Effect conc.:
1 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Reported statistics and error estimates:
LC50 values and their confidence intervals were calculated by means of a parametric model developed by Kooijman (1981).
Validity criteria fulfilled:
yes
Conclusions:
Based on the results of this study the LC50 is 0.75 mg/L.

Description of key information

In a study conducted according to DIN 38412 the acute toxicity of Acrolein cyanhydrin acetate (ACA) to the fresh-water fish Leuciscus idus was investigated. The 48h LC50 was determined to be 0.75 mg/l. (nominal).

Key value for chemical safety assessment

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