Registration Dossier
Registration Dossier
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EC number: 232-260-8 | CAS number: 7803-51-2
Endpoint summary
Administrative data
Description of key information
Newton et al. found a chronic NOAEC for rats at 3 ppm (4.3 mg/m3) (1999) and a subchronic NOAEC for rat at 3.1 ppm (4.4 mg/m3) (1993). Barbosa et al. (1994) found a subchronic NOAEC for mice at 1 ppm. These results indicated that mice may be more sensitive than rats.
Key value for chemical safety assessment
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEC
- 4.3 mg/m³
- Study duration:
- chronic
- Species:
- rat
Additional information
Newton et al. (1999) found no treatment-related changes suggestive of a toxic effect in F344 rats following 52 weeks or 2 years of whole-body inhalation exposure to 0.3, 1, or 3 ppm phosphine. Thus in this study 3 ppm is a chronic NOAEC for rats. 3 ppm (4.3 mg/m3)was set as the maximum level because in an earlier subchronic study in rats Newton et al. (1993) found lethality at 7 ppm. The effects of this study were reversible body-weight and feed-consumption decreases and lung and kidney histopathology in rats.
However, the chronic results of Newton et al. (1999) differ from the subchronic results of Newton et al. (1993), in which at least transient effects were seen in the hematopoietic system after 13 weeks at 3.1 ppm (4.4 mg/m3) (these effects were statistically significant but biologically questionable).
In a subchronic study in mice (Barbosa et al., 1994), 4.5 ppm (6.4 mg/m3) phosphine was a LOAEC (itching, decrease of weight gain, decrease of relative organ weights) and 1 ppm was a subchronic NOAEC (13 weeks) for decrease in body weight gain. These results indicated that mice may be more sensitive than rats.
On the basis of this information, a chronic NOAEC of 3 ppm (4.3 mg/m3) for rat is selected.
Justification for classification or non-classification
Phosphine is listed on Annex VI to Regulation (EC) No 1272/2008 includes lists of harmonised classification and labelling. No change is proposed for these effects.
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