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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Study period:
July 1973
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Test was conducted according to methods similar to OECD 402 (limit test) and was performed pre-GLP. A concise description of the protocol is available and results are acceptable as basic data. Furthermore, due to the read-across purpose it was given a Klimisch 2 rating, in accordance with the ECHA Practical guide #6 on the reporting of read-across in IUCLID. The justification for read across is provided in the attached background material of the chapter summary.
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Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report Date:
1973

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
In this skin irritation test of Grapefruit Oil 10 rabbits were used. There are no data on the test system and study design. Mortality, symptomatology, and skin irritation are recorded.
GLP compliance:
no
Remarks:
pre-GLP

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 73-21 Grapefruit oil

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Duration of treatment / exposure:
No data
Observation period:
No data
Number of animals:
10

Results and discussion

In vivo

Other effects:
No Symptomatology. Mortality: 1 out of 10 rabbbits died.

Any other information on results incl. tables

Slight redness - 6/10

Moderate redness - 2/10

Slight edema - 7/10

Moderate edema - 3/10

No information on scoring system used.

Applicant's summary and conclusion

Interpretation of results:
moderately irritating
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
Skin irritation results are as follows: Slight redness - 6/10; Moderate redness - 2/10; Slight edema - 7/10; Moderate edema - 3/10. No information on scoring system used is given. Based on these results, the substance is considered moderately irritating.
Executive summary:
In this skin irritation test of Grapefruit Oil 10 rabbits were used. No guideline has been followed and there are no data on the test system and study design. Mortality, symptomatology, and skin irritation are recorded. No symptoms have been observed. 1 out of 10 rabbits died. Skin irritation results are as follows: Slight redness - 6/10; Moderate redness - 2/10; Slight edema - 7/10; Moderate edema - 3/10. No information on scoring system used is given. Based on these results, the substance is considered moderately irritating.