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EC number: 204-008-7 | CAS number: 112-82-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
SKIN IRRITATION:
The irritation to the skin caused by exposure to 1-bromohexadecane was determined to be moderately irritating in a key study which was performed in line with OECD guideline 404 and EU Method B.4.
EYE IRRITATION:
The irritation to the eyes caused by exposure to 1-bromohexadecane was determined to be non-irritating in a key study which was performed in line with OECD guideline 405 and EU Method B.5.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin Irritation
A robust GLP compliant study has been used to address the skin irritation caused by exposure to the test material. Brunt (2003c) was performed in accordance with OECD guideline 404 and EU Method B.4. Three rabbits were exposed to 0.5 ml of the test material for 4 hours; the site was them observed at intervals over a period of 14 days. The test material was determined to be moderately irritating, scoring a PDII of 3.2 out of 8. All observed effects were fully reversible, and skin appeared normal by day 14. The study was performed to standardised guidelines and performed to a good standard; the study was assigned a reliability score of 1 using the principles for assessing data quality as set out in Klimisch (1977).
Eye Irritation
A robust GLP compliant study has been used to address the eye irritation caused by exposure to the test material. Brunt (2003d) was performed in accordance with OECD guideline 405 and EU Method B.5. Three New Zealand White rabbits were exposed to 0.1 ml of the test material and observed over a 72 hour period. The test material caused sufficient pain when administered that a local anaesthetic was used. Under the conditions of the test moderate conjunctiva irritation was observed at 1 hour being scored 8 out of 20 according to the Draize scale (1977). This was fully reversible within 24 hours. No other ocular effects were noted over the 72 hour observation period. The study was performed to standardised guidelines and performed to a good standard; the study was assigned a reliability score of 1 using the principles for assessing data quality as set out in Klimisch (1977).
Effects on skin irritation/corrosion: moderately irritating
Justification for classification or non-classification
Skin Irritation
Under Regulation 1272/2008 the test material is classified as a should be classed as "Skin Irrit. 2" with assigned the hazard phrase "H315: Causes Irritation to the Skin" and signal word "Warning".
Eye Irritation
The eye irritation study indicates that the test material has no effect which requires classification. Therefore the material does not require classification in line with Regulation 1272/2008.
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