Registration Dossier
Registration Dossier
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EC number: 204-008-7 | CAS number: 112-82-3
Endpoint summary
Administrative data
Description of key information
ACUTE TOXICITY: ORAL
The acute oral toxicity of 1-bromhexadecane was determined to be >2500 mg/kg according to the key study which was performed in line with OECD guideline 423.
ACUTE TOXICITY: DERMAL
The acute dermal toxicity of 1-bromohexadecane was determined to be > 2000 mg/kg according to the key study which was performed in line with OECD guideline 402 and EU Method B.3.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Value:
- mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Value:
- mg/kg bw
Additional information
Acute Toxicity: Oral
A robust GLP compliant study has been used to address acute oral toxicity. Brunt (2003a) was performed in accordance with OECD Guideline 423. The LD₅₀ of the test material was determined by exposing six female Sprague Dawley rats to a limit test of 2000 mg/kg. Under the conditions of the test no systemic signs of toxicity were reported over a period of 14 days and the LD₅₀ was determined to be >2500 mg/kg. The study was performed to standardised guidelines and performed to a good standard; the study was assigned a reliability score of 1 using the principles for assessing data quality as set out in Klimisch (1977).
Acute Toxicity: Dermal
A robust GLP compliant study has been used to address acute dermal toxicity. Brunt (2003b) was performed in accordance with OECD Guideline 402 and EU Method B.3. The LD₅₀ of the test material was determined by exposing ten Sprague Dawley rats to 2000 mg/kg in a limit test. Under the conditions of the test no systemic signs of toxicity were reported over a period of 14 days and the LD₅₀ was determined to be > 2000 mg/kg. The study was performed to standardised guidelines and performed to a good standard; the study was assigned a reliability score of 1 using the principles for assessing data quality as set out in Klimisch (1977).
Justification for classification or non-classification
Acute Toxicity: Oral
The acute oral toxicity study indicates that the test material has no effect which requires classification. Therefore the material does not require classification in line with Regulation 1272/2008.
Acute Toxicity: Dermal
The acute dermal toxicity study indicates that the test material has no effect which requires classification. Therefore the material does not require classification in line with Regulation 1272/2008.
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