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Environmental fate & pathways

Hydrolysis

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Description of key information

pH 4 and pH 7 at 50°C:  test substance is hydrolytically stable
pH 1.2 at 37°C: T1/2 = 4 days
pH 9.0 at 50°C: T1/2 = 4.8 days

Key value for chemical safety assessment

Additional information

The hydrolysis of the test item was assessed in aqueous buffers at pH 1.2, 4, 7 and 9 at 50 ± 0.5°C according to the OECD testing guideline 111. After 5 days, at pH 4, the test item was shown to be hydrolysed by less than 10% compared to T0. This indicated that it was hydrolytically stable and significant hydrolysis had not occurred under these conditions. At pH 7, the test item was shown to be hydrolysed by slightly upper than 10% compared to T0; in accordance with the study monitor, test item disappearance was not considered as significant, as a consequence the definitive test was conducted at pH 1.2 (37°C) and 9 (15, 37 and 50°C):

 The half life of the test item at pH 1.2 and 37°C was determined to be 4 days.

 The half life of the test item at pH 9.0 and 25°C was determined to be 4.8 days.

Hydrolysis was shown to have formed bis (hydroxymethyl) tricycle [5.5.1.0] decane.