Registration Dossier
Registration Dossier
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EC number: 700-080-3 | CAS number: 752225-55-1
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 50 mg/kg bw/day
Additional information
The subchronic application of the structural related ESBO to rats in doses up to 1.25 g/kg bw/d in the diet resulted in lower body weight gains in males. Liver weights were increased in rats fed either test article at 5% in diet; this increase was also observed in male rats fed either test article at 1%. Gross findings indicated a test article-related effect of ESBO on liver and kidney at 1% and 5%.
Rationale for read-across can be found in chapter 13
Repeated dose toxicity: via oral route - systemic effects (target organ) digestive: liver; urogenital: kidneys
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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