Registration Dossier

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Range-finding study.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report Date:
1973

Materials and methods

Test guideline
Guideline:
other: Range-finding test
Principles of method if other than guideline:
Range finding test
6 female Harlan-Wistar Albino rats were dynamically exposed to substantially saturated vapor of Dimethylaminopropyl Methacrylamide at 23.5 °C for 8 hours.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Specific details on test material used for the study:
- Name of test material (as cited in study report): Dimethylaminopropyl Methacrylamide
- Molecular weight (if other than submission substance): 170.25 g/mol

Test animals

Species:
rat
Strain:
Wistar
Sex:
female
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: ca. 100.6 gram.
- Fasting period before study: no data
- Housing: no data
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum): no data
- Acclimation period: no data


ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23.5 °C
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: no data
- Exposure chamber volume: no data
- Method of holding animals in test chamber: no data
- Source and rate of air: no data
- Method of conditioning air: no data
- System of generating particulates/aerosols: no data
- Method of particle size determination: no data
- Treatment of exhaust air: no data
- Temperature, humidity, pressure in air chamber: no data


TEST ATMOSPHERE
- Brief description of analytical method used: no data
- Samples taken from breathing zone: no
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
8 h
Remarks on duration:
at 23.5 °C
Concentrations:
saturated vapour
No. of animals per sex per dose:
6
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LCLo
Effect level:
other: dynamic exposure, saturated vapour at 23.5 °C
Exp. duration:
8 h
Remarks on result:
other: Died: 0/6, Signs of intoxication: None, Gross autopsy: Nothing remarkable
Mortality:
Dosage: Saturated vapour: Died: 0/6 female animals
Clinical signs:
other: None
Body weight:
Dosage mean body weight (g)
I T
saturated vapour 100.6 171.0
Gross pathology:
Nothing remarkable.

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
During the experiment 0/ 6 animals died therefore Dimethylaminopropyl methacrylamide is considered to be of low Toxicity based on the results on
female rats. No toxicity in a saturated atmosphere (23.5 °C, 8 hours).
Executive summary:

In an acute inhalation toxicity study (Range-finding test), 6 female Harlan-Wistar Albino rats (source: no data, age: no data, weight: ca. 100.6 gram), were dynamically exposed to substantially saturated vapour of Dimethylaminopropyl methacrylamide (purity: >=98%) for 8 hours at 23.5 °C.  Animals were then observed for 14 days.

 

Result: 0/ 6 animals died therefore Dimethylaminopropyl methacrylamide is of low toxicity based on the results on female rats.