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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2007-02-14 - 2007-03-30
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
OECD 107, non GLP, Study performed and documented equivalent to GLP standards. Study according to relevant guideline.
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Version / remarks:
Directive 92/69/EEC, Official Journal L 383 A)
GLP compliance:
no
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
0.5
Temp.:
24 °C
pH:
10.6

 

 Test condition

1

1

2

2

3

 3

Concentration in the buffer phase [mg/ml]

 0.9208

 0.9204

 0.7776

 0.7743

 0.6699

 0.6716

Mass in buffer phase [mg/ml]

33.1474

 33.1340

 20.9951

 20.9059

 12.0585

 12.0889

Concentration in octanol phase [mg]

 2.9553

 2.8959

 2.4155

 2.4431

 2.1140

 2.1151

Actual total mass [mg]

 53.1952

 52.1266

 65.2187

 65.9643

 76.1023

 76.1450

Calculated total mass [mg]

 86.3427

 85.2606

 86.2137

 86.8702

 88.1608

 88.2329
 pH in aqueous phase

    10.63

    10.64

    10.62

 Pow  3.2095  3.1463  3.1064  3.1552  3.1557  3.1493
 Log Pow  0.51  0.50  0.49  0.50  0.50  0.50

For all vessels there is good agreement between the actual and the calculated total mass. The log Pow values of the test item fall within a range of +/- units, thus the test is satisfactory

Conclusions:
log Pow = 0.50 at room temperature (24 °C).
Executive summary:

The log Pow is reported to be 0.50 at 24 °C measured according to OECD 107.

Description of key information

Log Kow (Pow) = 0.50 at  24 °C and pH 10.6 measured according to OECD 107 (Evonik Röhm Services, 2007)

Key value for chemical safety assessment

Log Kow (Log Pow):
0.5
at the temperature of:
20 °C

Additional information

OECD 107, Shake flask method