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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1987-12-17 to 1988-02-08
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Equivalent or similar to OECD guideline 401. No GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1988
Report date:
1988

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Version / remarks:
1981
Deviations:
not specified
GLP compliance:
no
Test type:
acute toxic class method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
1-(vinyloxy)octadecane
EC Number:
213-208-3
EC Name:
1-(vinyloxy)octadecane
Cas Number:
930-02-9
Molecular formula:
C20H40O
IUPAC Name:
1-(ethenyloxy)octadecane
Test material form:
other: colourless liquid

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Dr. Thomae GmbH; D-7950 Biberach; Germany
- Weight at study initiation: Males: 189 g; Females: 180 g
- Fasting period before study: about 16 hours
- Housing: Stainless steel wire mesh cages; type DK-III (Becker Co., Castrop-Rauxel, Germany)
- Diet: Kliba Labordiät 343, Klingentalmühle AG, CH-4303 Kaiseraugst, Switzerland, ad libitum
- Water: tap water ad libitum
- Acclimation period: at least 1 week

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12/12 (6 .00 - 18 .00 hours/18 .00 - 6 .00 hours )

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: olive oil
Details on oral exposure:
FASTING PERIOD
- Animals were given no feed about 16 hours before administration, but water was available at libitum

VEHICLE
- Test substance formulation with: olive oil
- Concentration in vehicle: 50 (w/v)
- Amount of vehicle (if gavage): 10 mL/kg
- Justification for choice of vehicle: test substance is insoluble in water

MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg


Doses:
5000 mg/kg
No. of animals per sex per dose:
10 (5 males/5 females) per dose
Control animals:
no
Details on study design:
- Time of day of observation: in the morning
- Duration of observation period following administration: 18 days
- Frequency of observations and weighing: observation: daily; weighing: day 0, 6 and 13
- Necropsy of survivors performed: yes
- Other examinations performed: gross pathological examination
Statistics:
NA

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
No mortalities
Clinical signs:
other: No clinical signs
Gross pathology:
No abnormalities

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information