Registration Dossier
Registration Dossier
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EC number: 203-977-3 | CAS number: 112-49-2
Endpoint summary
Administrative data
Description of key information
Skin irritation: 1 key study available: not irritating
Eye irritation: 1 key study available: irritating (according to EU Classification Labelling and Packaging Regulation (1272/2008/EC)
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
There is one reliable study available on the skin irritancy potential Triethylene glycol dimethyl ether was tested for its skin irritant properties in 6 Albino-Russian rabbits. The study was performed according to OECD Guideline 404. Deviation was a prolonged exposure period (24 hours). These conditions make the study design more rigid compared to the regarding OECD Guideline. No effects on skin occurred.
There is one reliable study available on the eye irritancy potential. Triethylene glycol dimethyl ether was tested for its eye irritant properties in 8 Albino-Russian rabbits. The study was performed equivalent to OECD Guideline 405. Effects on conjunctivae (mean score 2) and mean score (chemosis) 1 were observed in the animals after application.Effects on eye irritation: slightly irritating
Justification for classification or non-classification
With reference the reported scores of the observed effects to the skin Triethylene glycol dimethyl ether has not to be classified as irritant to the skin according to the criteria laid down in the EU Dangerous Substances Directive (67/548/EEC) and in the EU Classification Labelling and Packaging Regulation (1272/2008/EC).
With reference the reported scores and the absence reversibility of the observed effects to the eye Triethylene glycol dimethyl ether has not to be classified as irritant to the eye (R36 - irritant to the eyes) according to the criteria laid down in the EU Dangerous Substances Directive (67/548/EEC) and but has to be classified as eye irritant (H319 - Causes serious eye irritation) according to the criteria laid down in the EU Classification Labelling and Packaging Regulation (1272/2008/EC).Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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