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Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Description of key information

With high probability acutely not harmful to aquatic invertebrates

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
308 mg/L

Additional information

One toxicity test on freshwater invertebrates isavailable. This static test was carried out following EU Directive 79/831/EEC, which is comparable to the OECD guideline 202. The determined EC50 is > 100 mg/L [BASF AG, 1991].

The study design and the lack of analytical verification of exposure concentrations limit the adequacy of the study to address the acute toxicity of the substance, which has potential to evaporate from the test system due to its physical-chemical properties

However, based on its chemical structure, 1,3-dioxepane is expected to exert acute aquatic toxicity through a narcotic mode of action (narcosis or baseline toxicity) and therefore the endpoint can be adequately estimated from its structure. Estimations of short-term toxicity to aquatic invertebrates conducted with two valid QSAR methods confirm the very low toxicity of 1,3 -dioxepane to aquatic invertebrates and support the result of the available experimental study.

A EC 50 (48 h) of 308 mg/L (estimated by the OECD Tollbox 4.1) is taken for chemical safety assessment.

In conclusion, taking together the available experimental data and the QSAR predictions and using a weight-of-evidence approach, a LC50 (96 h) of > 100 mg/l can be estimated for aquatic invertebrates.