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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

With high probability acutely not harmful to fish

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
1 420 mg/L

Additional information

One toxicity test on freshwater fish is available. This static test was carried out according to German national standards (DIN 38412). The determined LC50 for Leuciscus idus ranges between 2200 and 4600 mg/L [BASF AG, 1987]. The NOAEC was estimated to be 1000 mg/L.

The study design and the lack of analytical verification of exposure concentrations limit the adequacy of the study to address the acute toxicity of the substance, which has potential to evaporate from the test system due to its physical-chemical properties

However, based on its chemical structure, 1,3-dioxepane is expected to exert acute aquatic toxicity through a narcotic mode of action (narcosis or baseline toxicity) and therefore the endpoint can be adequately estimated from its structure. Estimations of short-term toxicity to fish conducted with two valid QSAR methods confirm the very low toxicity of 1,3 -dioxepane to fish and support the result from the available experimental study.

A LC50 (96 h) of 1420 mg/L (estimated by OECD Toolbox 4.1) is taken for the chemical safety assessment.

In conclusion, taking together the available experimental data and the QSAR predictions and using a weight-of-evidence approach, a LC50 (96 h) of > 1000 mg/l can be estimated.