Registration Dossier

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Acute toxicity tests covering all three trophic levels (fish, invertebrates and green algae) are available for 1,3 -dioxepane .

L(E)C50 values derived from these studies are all above 100 mg/L.

The study design and the lack of analytical verification of exposure concentrations limit however the adequacy of the studies to address the acute toxicity of the substance, which has potential to evaporate from the test system due to its physical-chemical properties.

Nevertheless, based on its chemical structure, 1,3-dioxepane is expected to exert acute aquatic toxicity through a narcotic mode of action (narcosis or baseline toxicity) and therefore the aquatic toxicity can be adequately estimated from its structure. Estimations of short-term toxicity to fish, daphnids and green algae conducted with two valid QSAR methods confirm the very low toxicity of 1,3 -dioxepane to fish and support the result from the available experimental study.

Additional information