Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 208-015-6 | CAS number: 505-65-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Not readily biodegradable according to OECD criteria.
Additional information
A respirometer test according to OECD guideline 301 F performed by BASF (1981) shows a biodegradion rate of 10 - 30 % after 28 days. This result is supported by a QSAR estimation carried out with CATALOGIC 301 C (v10.14 June,2017). A biodegradation of 2% after 28 is estimated. The prediction is considered as reliable since the molecule falls into parametric, structural and metabolic domain of the model. The substance is therefore assessed in a weight-of-evidence approach as not readily biodegradable according to OECD criteria.
Metabolites potentially formed during biodegradation of 1,3 -dioxepane were also modelled using CATALOGIC 301C and are listed in the following table
Level |
Quantity |
LogKow |
Smiles |
BOD |
0 |
0.9821 |
0.6749 |
C1CCCOCO1 |
0.02 |
1 |
8.95E-08 |
-0.8634 |
OC1CCCOCO1 |
0.93 |
1 |
8.95E-13 |
-0.8634 |
OC1OCCCCO1 |
0.98 |
2 |
8.95E-08 |
-1.4140 |
OCOCCCC=O |
0.93 |
2 |
8.95E-08 |
-0.1657 |
OCCCCOC=O |
0.98 |
3 |
8.95E-08 |
-1.1613 |
OCOCCCC(O)=O |
0.93 |
3 |
8.95E-08 |
0.0953 |
OCCCCOC(O)=O |
0.98 |
4 |
8.95E-08 |
-0.3958 |
OCCCC(O)=O |
0.91 |
4 |
8.95E-08 |
0.3500 |
C=O |
1.00 |
4 |
8.95E-08 |
0.0706 |
OC(=O)OCCCC=O |
0.98 |
5 |
8.95E-08 |
-0.4205 |
OC(=O)CCC=O |
0.91 |
5 |
8.95E-08 |
-0.4605 |
OC=O |
1.00 |
5 |
8.95E-08 |
-0.2632 |
OC(=O)CCCOC(O)=O |
0.97 |
6 |
0.0009204 |
-0.7543 |
OC(=O)CCC(O)=O |
0.90 |
6 |
8.95E-08 |
-0.4782 |
OC(=O)C=CCOC(O)=O |
0.97 |
7 |
8.03E-08 |
0.5779 |
CCC(O)=O |
1.00 |
7 |
8.95E-08 |
-1.8015 |
OC(CC(O)=O)COC(O)=O |
0.97 |
8 |
8.95E-05 |
-1.8129 |
OC(=O)CC(=O)COC(O)=O |
0.97 |
9 |
0.000984 |
-1.2454 |
OC(=O)COC(O)=O |
0.91 |
9 |
8.95E-08 |
0.0868 |
CC(O)=O |
1.00 |
10 |
7.96E-08 |
-1.0666 |
OCC(O)=O |
1.00 |
11 |
7.96E-08 |
-1.4027 |
OC(=O)C=O |
1.00 |
12 |
7.96E-08 |
-1.7365 |
OC(=O)C(O)=O |
1.00 |
Considering the BOD predictions and the estimated Log Kow values, it is assumed that no one of the predicted potential metabolites can be identified as relevant degradation product in terms of PBT/vPvB assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
