Registration Dossier
Registration Dossier
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EC number: 241-753-7 | CAS number: 17772-51-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3-hydroxy-2-(3-hydroxy-2-quinolyl)-1H-inden-1-one
- EC Number:
- 241-753-7
- EC Name:
- 3-hydroxy-2-(3-hydroxy-2-quinolyl)-1H-inden-1-one
- Cas Number:
- 17772-51-9
- Molecular formula:
- C18H11NO3
- IUPAC Name:
- 3-hydroxy-2-(3-hydroxyquinolin-2-yl)-1H-inden-1-one
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Test item Macrolex Gelb G
Chemical name 3-Hydroxy-2-(3-hydroxy-2-quinolyl)-1H-inden-1-one
CAS no. 17772-51-9
Molecular formula C18H11NO3
Molecular mass 289.3 g/mol
Batch no. CHT23240
Appearance orange powder
Content of test item 98.8 % (not used for calculation)
Confirmation of the identity of the test item was performed.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- not required
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- discriminating dose
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
Groups of 5 male and 5 female Wistar rats received a single dermal dose of 2000 mg/kg body weight of the test item applied semiocclusively for 24 hours.
A dose of 2000 mg/kg body weight was tolerated by male and female rats without toxicologically relevant clinical signs, mortalities, toxicological effects on body weight development and gross pathological findings.
Applicant's summary and conclusion
- Executive summary:
Groups of 5 male and 5 female Wistar rats received a single dermal dose of 2000 mg/kg body weight of the test item applied semiocclusively for 24 hours.
A dose of 2000 mg/kg body weight was tolerated by male and female rats without toxicologically relevant clinical signs, mortalities, toxicological effects on body weight development and gross pathological findings.
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