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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1989
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Early study not conducted according to actual guidelines or GLP; experimental method reliable but limited or insufficient information on compound characterisation and analytics available.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1989

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
yes
Principles of method if other than guideline:
4 hours inhalation study; head-nose inhalation system.
GLP compliance:
no
Test type:
other: head-nose inhalation
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
3-hydroxy-2-(3-hydroxy-2-quinolyl)-1H-inden-1-one
EC Number:
241-753-7
EC Name:
3-hydroxy-2-(3-hydroxy-2-quinolyl)-1H-inden-1-one
Cas Number:
17772-51-9
Molecular formula:
C18H11NO3
IUPAC Name:
3-hydroxy-2-(3-hydroxyquinolin-2-yl)-1H-inden-1-one
Test material form:
other: solid
Details on test material:
Oxichinophthlon Stücke Ber. 100%

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
nose/head only
Vehicle:
other: 1 wt% aerosil (E200)
Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
4 h
Concentrations:
Mean analytical concentration: 5.8 mg/l; MMAD: 4.1 µm
No. of animals per sex per dose:
5 males and 5 females
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC0
Effect level:
5 mg/L air (analytical)
Exp. duration:
4 h

Any other information on results incl. tables

No death occured; clinical observations: accelerated respiration, fur discolored with test substance, stagging unsteady gait.

Applicant's summary and conclusion

Executive summary:

No death occured; clinical observations: accelerated respiration, fur discolored with test substance, stagging unsteady gait.