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EC number: 281-897-8 | CAS number: 84057-80-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 30 oct 2000 to 29 nov 2000
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to the OECD internationally recognised guideline, but the GLP are not stated, and no analytics were performed.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: The substance practically insoluble in water, was introduced in the test medium by weighed adequate quantity and was dispersed by stirring. The dissolution was continued during a period of 168 hours to be sure that the equilibrium was reached and "soluble fraction" stable during the test. After correction of evaporation by addition of deionised water, stirring was stopped and the different suspensions were decanted for a resting period of 4 hours.
- Controls: yes, test water without test item
- Evidence of undissolved material (e.g. precipitate, surface film, etc): no - Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Zebrafish
- Source: Pisciculture Exotique - Dourdan, 91, France
- size/weight: 30.4 mm, 0.3 g;
- Method of breeding: The fish were bred in reconstituted water (ISO 7346) with continual aeration and filtering device
- Food: TetraMin Tetra during breeding (no feeding during the test);
ACCLIMATION
- Acclimation period: 2 weeks
- Acclimation conditions: same as test
- Health during acclimatation: mortality less than 1% within the adaptation period. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- none
- Hardness:
- 250 mg/L +/- 25 mg/L as CaCO3.
- Test temperature:
- 24°C +/- 1°C
- pH:
- 7.17-7.83
- Dissolved oxygen:
- 4.5-8.2 mg/L
- Salinity:
- not applicable
- Nominal and measured concentrations:
- 100 mg/l
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type : 5 litres glass beakers
- Fill volume: 4 L of reconstituted water
- Aeration: none during the test, but dilution water was previously saturated with oxygen before the start of the test
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Biomass loading rate: 0.76 g/L
WATER PARAMETERS
- Source: reconstituted water-ISO 7346
- Conductivity: < 5 µs/cm
- Intervals of water quality measurement : pH and dissolved oxygen were measured after 0, 24, 48, 72 and 96 h of exposure
- No further data
OTHER TEST CONDITIONS
- Photoperiod: about 12 h light daily
- Light intensity: natural diffused lighting
EFFECT PARAMETERS MEASURED : Immobility and absence of respiration motion observed after 3, 24, 48, 72 and 96 h of exposure - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Duration:
- 96 h
- Dose descriptor:
- LL50
- Effect conc.:
- > 74 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- element (total fraction)
- Remarks:
- Zr
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LL50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (total fraction)
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOELR
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (total fraction)
- Basis for effect:
- mortality (fish)
- Details on results:
- No mortality was observed during the test, either in control or test groups.
No abnormal response of the fish was observed during the test period. - Results with reference substance (positive control):
- - Results with reference substance valid? yes
- Mortality: no data
- 24h LC50: 226 mg/L (K2Cr2O7). This calculated value was between the interval (200-400 mg/L) formely defined by the method, and was used to validate the selected fish batch. - Validity criteria fulfilled:
- yes
- Conclusions:
- Using a limit test at 100 mg/L, zirconium dioxide had no acute toxic effect on the fish Danio rerio.
- Executive summary:
The 96hr-acute toxicity of zirconium dioxide to Brachydanio rerio was studied under static conditions, according to OECD Guideline 203. Fish were exposed to control and test chemical at nominal concentration of 100 mg /L. Mortality/immobilization were observed daily. No mortality was observed during the test, neither in the control nor in the group exposed to the test item. The 96 hour LL50 and NOELR were thus > 100 mg/L.
Reference
Description of key information
The 96hr-acute toxicity of zirconium dioxide to Brachydanio rerio was studied under static conditions, according to OECD Guideline 203. Fish were exposed to control and test chemical at nominal concentration of 100 mg/L. Mortality/immobilization were observed daily. No mortality was observed during the test, neither in the control nor in the group exposed to the test item. The 96 hour LL50 and NOELR were thus > 100 mg/L zirconium dioxide, equivalent to > 74 mg Zr/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- > 74 mg/L
Additional information
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