Registration Dossier
Registration Dossier
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EC number: 219-460-0 | CAS number: 2439-35-2
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Adequacy of study:
- other information
Data source
Reference
- Title:
- No information
- Author:
- Ministry of Environment, Japan(1997a): unpublished report on|Fish, Acute Toxicity Test (No. 6B715G)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-(dimethylamino)ethyl acrylate
- EC Number:
- 219-460-0
- EC Name:
- 2-(dimethylamino)ethyl acrylate
- Cas Number:
- 2439-35-2
- Molecular formula:
- C7H13NO2
- IUPAC Name:
- 2-(dimethylamino)ethyl prop-2-enoate
- Details on test material:
- IUCLID4 Test substance: as prescribed by 1.1 - 1.4
TS-Freetext:
SOURCE: Wako Pure Chemical Industries, LTD (Japan)
PURITY: 99.9%
IMPURITY/ADDITIVE/ETC.: not described
ANY OTHER INFORMATION: Lot No.SKK4558, got on Dec.25,1996
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test organisms
- Test organisms (species):
- Oryzias latipes
Study design
- Test type:
- semi-static
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 8.49 mg/L
Any other information on results incl. tables
- Sublethal observations / clinical signs:
RS-Freetext:
RESULTS: EXPOSED
- Measured concentrations: in these stock solution
(10,000 mg/L)
immediately after the preparations
Nominal Measured concentration [mg/L]
concentration 1st preparation (% of nominal)
[mg/L]
10,000 8,930
(89)
ND = 10 mg/L
- Effect data (Mortality):
Nominal Cumulative Mortality (% Mortality)
concentration
[mg/L] 24 hr 48 hr 72 hr 96 hr
Control 0 (0) 0 (0) 0 (0) 0 (0)
6.00 0 (0) 0 (0) 0 (0) 0 (0)
12.0 4 (40) 0 (100) 10 (100) 10 (100)
24.0 10 (100) 10 (100) 10 (100) 10 (100)
24 hr LC50 = 13.1 mg/L (95%c.l. = 6.00 - 24.0 mg/l)
48 hr LC50 = 8.49 mg/L (95%c.l. = 6.00 - 12.0 mg/L)
72 hr LC50 = 8.49 mg/L (95%c.l. = 6.00 - 12.0 mg/L)
96 hr LC50 = 8.49 mg/L (95%c.l. = 6.00 - 12.0 mg/L)
96 hr lowest concentration resulting in 100% mortality
= 12.0 mg/L
96 hr highest concentration resulting in 0% mortality
=6.0 mg/L
- Other effects:
Nominal Symptom of toxicity observed
concentration
[mg/L] 24 hr 48 hr 72 hr 96 hr
Control N N N N
Solvent control N N N N
6.00 N N N N
12.0 AS-1 -- -- --
AQ-1
24.0 -- -- -- --
48.0 -- -- -- --
96.0 -- -- -- --
Note; N : No toxicological symtom was observed
-- : All fish were dead at this observation time
AS : abnormal swimming
AQ : paralyzation
RESULTS: CONTROL
- Nature of adverse effects: none
RESULTS: TEST WITH REFERENCE SUBSTANCE
- Reference substance: CuSO4·5H2O
- Results: 96 hr LC50 = 0.44 mg/L and 0.80 mg/L
Applicant's summary and conclusion
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