Registration Dossier

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: An LC50 study was mentioned in the IUCLID 2000 dossier, however only very few details are available.

Data source

Reference
Reference Type:
secondary source
Title:
LC50 of Substance 577-11-7
Author:
ECB
Year:
2000
Bibliographic source:
IUCLID Datasets

Materials and methods

Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
AEROSOL OT 100%

Test animals

Species:
rat

Administration / exposure

Route of administration:
other: no experimental data provided
Duration of exposure:
96 h

Results and discussion

Effect levels
Dose descriptor:
LC50
Effect level:
20 mg/L air
Based on:
act. ingr.
Exp. duration:
96 h

Applicant's summary and conclusion

Conclusions:
LC50 = 20 mg/L
Executive summary:

Exposure of rats to docusate sodium for 96 hours led to an LC50 of 20 mg/L.