Registration Dossier
Registration Dossier
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EC number: 231-308-5 | CAS number: 7491-09-0
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
Based on read across to the corresponding substance with sodium as cationic part instead of potassium the partition coefficient was determined to 1.998
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.998
- at the temperature of:
- 20 °C
Additional information
According to EU method A.8 (2008) the shake flask and HPLC methods are "not applicable to surface active materials (for which a calculated value or an estimate based on the individual n-octanol and water solubilities should be provided)".
Docusate sodium is a surfactant. Therefore, the value of the partition coefficient was calculated using the solubilities of the test substance in the pure solvents as proposed in EU method A.8 (2008) Appendix 1. Docusate Sodium is soluble in water (8.17 g/L) and n-octanol (814 g/L). Based on this information, the log Pow is 1.998. This value is considered to be reliable and relevant.
For the risk assessment a log Pow of 1.998 will be used.
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