Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

The potential for tertiary butyl acetate to cause dermal sensitization is well understood. In the key study, a Buehler test conducted according to EPA OPP Guideline 81-6, a concentration of 100% tertiary butyl acetate at challenge did not cause a sensitization reaction in ten male guinea pigs previously induced with three separate six-hour epicutaneous, occlusive exposures performed once per week for three weeks.

Justification for classification or non-classification

No evidence of a sensitization response was observed in a guideline dermal sensitization study conducted in guinea pigs. Tertiary butyl acetate is not classified for dermal sensitization according to EU CLP (Regulation (EC) No. 1272/2008) and UN GHS.