Registration Dossier
Registration Dossier
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EC number: 225-969-9 | CAS number: 5188-07-8
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Sodium methanethiolate was tested in an OECD Test Guideline 406 skin sensitization study (maximization test) with guinea pigs (Clouzeau, 1994). Induction was accomplished by an intradermal injection of a 1% solution of sodium methanethiolate in Freund’s adjuvant on day 1 followed by a topical application of a 1% solution of sodium methanethiolate on day 8 (covered for 48 hours) to 10 animals/sex in the treated group and 5 animals/sex in the control. On day 22, a challenge dose of a 10% solution of sodium methanethiolate was applied topically (covered for 24 hours). Skin reactions were evaluated 24 and 48 hours following the removal of the dressing after the challenge dose. No clinical signs or deaths were observed. At 24 and 48 hours following the removal of the dressing after the challenge dose, no cutaneous reactions were recorded. It was concluded that sodium methanethiolate is not a skin sensitizer. Satisfactory sensitization response was observed using the positive control, dinitrochlorobenzene.
Migrated from Short description of key information:
According to the maximization method established by Magnusson and Kligman, no cutaneous reactions attributable to the sensitization potential of sodium methanethiolate at the maximum non-irritant concentration of 10% were observed in guinea-pigs.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
- Migrated from Short description of key information:
No data available.
Justification for classification or non-classification
According to REGULATION (EC) No 1272/2008 and DIRECTIVE 67/548/EEC and the available skin sensitization data, sodium methylmercaptide should not be classified as a skin sensitiser.
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