Registration Dossier
Registration Dossier
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EC number: 254-471-4 | CAS number: 39489-75-3
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP screening study
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
- Principles of method if other than guideline:
- Mouse local lymph node assay (LLNA)
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Bis(2,4-dichloro-5-nitrophenyl) carbonate
- EC Number:
- 254-471-4
- EC Name:
- Bis(2,4-dichloro-5-nitrophenyl) carbonate
- Cas Number:
- 39489-75-3
- Molecular formula:
- C13H4Cl4N2O7
- IUPAC Name:
- bis(2,4-dichloro-5-nitrophenyl) carbonate
- Details on test material:
- - Name of test material (as cited in study report): di(2,4-dichloro 5-nitrophenyl) carbonate (DDNC)
- Storage condition of test material: stored in the dark at room temperature in air-tight containers
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
Results and discussion
Any other information on results incl. tables
No indication of the test results provided
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the test conditions, Bis(2,4-dichloro-5-nitrophenyl) carbonate is not a skin sensitiser in the mouse local lymph node assay.
- Executive summary:
In a mouse local lymph node assay performed in compliance with the GLP, Bis(2,4-dichloro-5-nitrophenyl) carbonate (named as di(2,4-dichloro 5-nitrophenyl) carbonate (DDNC))has no skin sensitisation potential. It is therefore not classified for skin sensitisation according to the Regulation (EC) 1272/2008 and the Directive 67/548/EEC according to this test.
However 2 human cases with skin sensitisation after contact with Bis(2,4-dichloro-5-nitrophenyl) carbonate
were reported. Therefore the submitted substance hould be classified as Skin sens. 1 (H317) according to the Regulation (EC) 1272/2008 (CLP) and as Xi, R43 according to the Directive 67/548/EEC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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