(S)-1,2-epoxypropane

Genetic toxicity: in vitro

Administrative data

Endpoint:

genetic toxicity in vitro

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Study period:

2002

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Cited experiments were summarized in the European Chemicals Bureau Methyloxirane (Propylene Oxide) Risk Assessment Report. The original studies were not reviewed.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

review article or handbook

Title:

Unnamed

Year:

2002

Materials and methods

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

propylene oxide

IUPAC Name:

propylene oxide

Constituent 2

Reference substance name:

Methyloxirane

EC Number:

200-879-2

EC Name:

Methyloxirane

Cas Number:

75-56-9

IUPAC Name:

2-methyloxirane

Applicant's summary and conclusion

Conclusions:

Propylene oxide has been shown to cause mutation in S. typhimurium, E. coli and K. pneumoniae. Propylene oxide also induced chromosome and chromatid breaks and chromosome exchanges in chromosome aberration assays.