Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
repeated dose toxicity: inhalation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
2002
Reliability:
2 (reliable with restrictions)
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2002

Materials and methods

GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
propylene oxide
IUPAC Name:
propylene oxide
Constituent 2
Reference substance name:
Methyloxirane
EC Number:
200-879-2
EC Name:
Methyloxirane
Cas Number:
75-56-9
IUPAC Name:
2-methyloxirane

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
In rats and mice, repeated inhalation exposure to propylene oxide for 2 years produced chronic irritation of the nasal epithelium, with such effects being only marginal in nature at 30 ppm. However, concentrations of 100 ppm and above produced epithelial damage. In a 4 -week study in rats, small and reversible increases in nasal epithelium irritation occurred at 525 ppm propylene oxide. There is some evidence to indicate neurotoxicity in rats at a relatively high exposure level of 1,500 ppm after 7 weeks of exposure. No signs of neurotoxicity were observed in rats exposed to 300 ppm for 24 weeks.