Registration Dossier

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Additional information:
Migrated from Short description of key information:
There have been no conventional studies of skin sensitisation potential with propylene oxide application to animal skin. In the only available study,
the result was negative. Overall, although the evidence is unclear, propylene oxide has demonstrated some potential to cause skin sensitisation and
given the alkylating properties of the substance, it is plausible that it could bind to tissue proteins to produce a hapten and hence elicit an
immunological response. There are no reports of propylene oxide causing respiratory sensitisation and it is not possible to draw any conclusions
regarding this endpoint. Based upon the available data, no classification for sensitisation is proposed.

Justification for classification or non-classification