Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

A skin irritation study in animals performed to regulatory standards is not available. A relatively old study in rabbits indicated that application of undiluted or 10-20% aqueous propylene oxide may cause signs of skin irritation within minutes and scar formation with more lengthy exposures. In a more recent study, in which propylene oxide may have evaporated from the test sites, no skin irritation was observed. Overall, it appears that propylene oxide liquid may cause local irritation on contact with the skin. In light of eye irritation following exposure to propylene oxide vapour, it is considered that the liquid also has the potential to produce eye irritation. Classification according to Annex I of Directive 67/548/EC is proposed as follows: R36/37/38 Irritating to Eyes, Respiratory System and Skin. 

Key value for chemical safety assessment

Additional information

Justification for classification or non-classification