Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
2002
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Cited experiments were summarized in the European Chemicals Bureau Methyloxirane (Propylene Oxide) Risk Assessment Report. The original studies were not reviewed.
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2002

Materials and methods

GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
propylene oxide
IUPAC Name:
propylene oxide
Constituent 2
Reference substance name:
Methyloxirane
EC Number:
200-879-2
EC Name:
Methyloxirane
Cas Number:
75-56-9
IUPAC Name:
2-methyloxirane

Results and discussion

Applicant's summary and conclusion

Conclusions:
A single oral dose in the rat, by gavage, of 1,000 mg/kg resulted in 100% mortality, while no deaths occurred at 300 mg/kg. This suggests that the
LD50 is below 1,000 mg/kg and the slope of the dose-effect relationship is quite steep.

A rat LD50 of 1.14 mL/kg (950 mg/kg) has also been reported. In another study, the oral LD50 values for the rat, mouse and guinea pig were
reported to be 520 mg/kg, 630 mg/kg and 660 mg/kg, respectively. A guinea pig LD50 of 690 mg/kg has also been reported.