Registration Dossier
Registration Dossier
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EC number: 642-362-8 | CAS number: 1190630-03-5
Endpoint summary
Administrative data
Description of key information
Skin Irritation/Corrosion
The key study for skin irritation/corrosion was a reliable (Klimisch 1) OECD 404 study with docosan-1-ol. In this study docosan-1-ol was considered not to be a skin irritant when applied to rabbit skin.
Eye Irritation
The key study for eye irritation was a reliable (Klimisch 1) OECD 405 study with docosan-1-ol. In this study docosan-1-ol was considered not to be an eye irritant.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Ziegler Bottoms are characterized as comprising of two primary constituents; icosan-1-ol and docosan-1-ol. Together these constituents represent a structural class of components (alcohols) that constitute approximately 82% of the composition of Ziegler Bottoms. Study data, where available, for each of these primary constituents has been evaluated and considered together. In a conservative approach the most sensitive study result from across the two constituents has been identified and used to address the endpoint in question.
Skin Irritation/Corrosion
A reliable (Klimisch 1) OECD 404 study was conducted with docosan-1-ol. Rabbits were treated with undiluted docosan-1-ol in a 4 hour semi-occlusive exposure. No evidence of skin irritation was noted during the study other than very slight erythema at one test site at 1 hour after patch removal. All other scores were 0. Docoson-1-ol was considered not irritating to rabbit skin. Consequently in line with the read-across justification included, Ziegler Bottoms are considered to be non-irritating.
Eye Irritation
A reliable (Klimisch 1) OECD 405 was conducted with docosan-1-ol. Moderate conjunctival irritation was reported in all animals one hour after treatment with minimal to moderate conjunctival irritation at the 24 hour observation time. At 48 hours minimal conjunctival redness was observed in one animal only. All scores were 0 at 72 hours. Docoson-1-ol was considered not irritating to the rabbit eye. Consequently in line with the read-across justification included, Ziegler Bottoms are considered to be non-irritating to eyes.Justification for classification or non-classification
These findings do not warrant the classification of Ziegler Bottoms as skin or ocular irritants under the new Regulation (EC) 1272/2008 on classification, labelling and packaging of substances and mixtures (CLP) and under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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