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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific principles, acceptable for assessment. Study considered valid although result reporting is limited.

Data source

Reference
Reference Type:
publication
Title:
Range-finding toxicity data: List VII.
Author:
Smyth H F, Carpenter C P, Weil C S, Pozzani U C, Striegel J A, Nycum J S
Year:
1969
Bibliographic source:
Am. Ind. Hyg. Assoc. J. 30(5): 470-476

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Method: other: Smyth et al, 1962
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Automatically generated during migration to IUCLID 6, no data available
IUPAC Name:
Automatically generated during migration to IUCLID 6, no data available
Details on test material:
icosanol (mixed isomers)

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male
Details on test animals or test system and environmental conditions:
- Source: no data
- Weight at study initiation: 2.5 -3.5 kg
- Group size: 4
- Controls: no



Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
- Area covered: entire trunk

No. of animals per sex per dose:
4

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 20 mL/kg bw

Any other information on results incl. tables

Results were not reported in detail. The LD50 was >20 ml/kg. (>16,800 mg/kg using the density of 0.84 g/cm3 reported in chapter 2.3). No further 

details available.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
An LD50 value of >20ml/kg is reported in a study which even though lacking in detail is deemed reliable and equivalent to guideline.