Registration Dossier
Registration Dossier
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EC number: 642-362-8 | CAS number: 1190630-03-5
Toxicity to birds
Administrative data
Link to relevant study record(s)
Description of key information
Ziegler Bottoms are characterised according to two constituents; icosan-1-ol and docosan-1-ol. In accordance with REACH Annex X, the requirement for an avian toxicity study is waived on the basis of the absence of toxicity to mammals. In addition, the substance is unlikely to accumulate through the food chain.
Key value for chemical safety assessment
Additional information
Ziegler Bottoms are characterized as comprising of two primary constituents; icosan-1-ol and docosan-1-ol. Together these constituents represent a structural class of components (alcohols) that constitute approximately 82% of the composition of Ziegler Bottoms. Study data, where available, for each of these primary constituents has been evaluated and considered together. In a conservative approach the most sensitive study result from across the two primary constituents has been identified and used to adequately address the Ziegler Bottoms endpoint in question.
The requirement for long-term avian testing is waived in view of the lack of toxic effects in mammals. Chronic and sub-chronic mammalian toxicity studies have shown that long chain alcohols (LCA) are of low toxicity. Furthermore, combined repeated-dose studies with developmental endpoints, as well as reproductive and developmental studies, showed no effects at the highest dose tested. Using this evidence it is assumed that the test substance is not considered to be toxic (in PBT terms) to mammals and secondary poisoning is unlikely to occur in the environment.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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