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EC number: 642-362-8 | CAS number: 1190630-03-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The short-term toxicity in invertebrates of components of Ziegler Bottoms has been documented within this dossier. In a conservative approach the most sensitive study result from across the two primary constituents of Ziegler Bottoms has been identified and used to address the hazard endpoint in question. The most sensitive study result from across the two substances has been identified as a reliable study with docosan-1-ol (Fisk et al. 2009) where the 96 hr LC50 was predicted at >100 mg/L. However, the predicted LC50 is greater than the limit of solubility (>LoS, which is 0.1 mg/L). It is concluded that under circumstances when the predicted LC50 is greater than the LoS, the substance is not considered to be toxic.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Ziegler Bottoms are characterized as comprising of two primary constituents; icosan-1-ol and docosan-1-ol. Together these constituents represent a structural class of components (alcohols) that constitute approximately 82% of the composition of Ziegler Bottoms. Study data, where available, for each of these primary constituents has been evaluated and considered together. In a conservative approach the most sensitive study result from across the two constituents has been identified and used to address the endpoint in question.
Several reliable (Klimisch 1 or 2) short-term toxicity studies in invertebrates have been conducted for constituents of Ziegler Bottoms and are included in this dossier. The reliable studies included for each constituents briefly described below. In a conservative approach the most sensitive study result from across the two constituents will be identified and used to address the hazard endpoint in question.
Icosan-1-ol
There were no reliable measured data for short-term toxicity of icosan-1-ol to invertebrates. However, Fisk et al (2009) provided reliable (Klimisch 2) predicted results for short-term toxicity of icosan-1-ol to invertebrates using a validated QSAR model based on measured data available across the alcohols category and the Log Kow of the substance. Fisk et al. (2009) predicted a 96hr LC50 of >100 mg/L for short ¿term toxicity to invertebrates when exposed to icosan-1-ol. The result was compared to the limit of solubility (LoS) and for this substance the predicted LC50 is greater than the limit of solubility (>LoS, which is 0.102 mg/L). It is concluded that under circumstances when the predicted LC50 is greater than the LoS, the substance is not considered to be toxic.
Docosan-1-ol
Fisk et al. (2009) provided reliable (Klimisch 2) predicted results for the short-term toxicity of docoosan-1-ol toDaphnia magnausing a validated QSAR based on measured data available across the alcohols category and the Log Kow of the substance. Fisk et al. (2009) predicted a 96hr LC50 of >100 mg/L for short ¿term toxicity toDaphnia magnawhen exposed to docosan-1-ol. The result was compared to the limit of solubility (LoS) and for this substance the predicted LC50 is greater than the limit of solubility (>LoS, which is 0.1 mg/L). It is concluded that under circumstances when the predicted LC50 is greater than the LoS, the substance is not considered to be toxic.
The short-term toxicity in invertebrates of components of Ziegler Bottoms has been documented within this dossier. Adequate reliable predicted data exists for short-term toxicity to invertebrates to components of Ziegler Bottoms (namely, icosan-1-ol and docosan-1-ol). In a conservative approach the most sensitive study result from across the two constituents has been identified and used to address the hazard endpoint in question. The most sensitive study result from across the two substances has been identified as a reliable study with docosan-1-ol (Fisk et al., 2009) where the 96 hr LC50 was predicted at >100 mg/L. However, the predicted LC50 is greater than the limit of solubility (>LoS, which is 0.1 mg/L). It is concluded that under circumstances when the predicted LC50 is greater than the LoS, the substance is not considered to be toxic.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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