Registration Dossier
Registration Dossier
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EC number: 939-600-0 | CAS number: 1471316-27-4
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Summary of toxicological information. Therefore only limited data are available.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
- Principles of method if other than guideline:
- 0.1 mL of the test substance was instilled into the right eye of each of six New Zealand White rabbits. No details available.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 25231-21-4
- EC Number:
- 607-655-7
- Cas Number:
- 25231-21-4
- IUPAC Name:
- 25231-21-4
- Test material form:
- not specified
- Details on test material:
- - Test material: alcohol C18, 15PO
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- not specified
- Controls:
- not required
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- No data
- Observation period (in vivo):
- No data
- Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: unknown
- Score:
- 0
- Remarks on result:
- other: Details on time point are not reported.
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: unknown
- Remarks on result:
- other: Details on time point and score are not reported.
- Irritant / corrosive response data:
- No corneal opacity was observed. Slight irritation of the conjunctiva was observed in 5/6 animals. According to the scoring system of Kay&Calandra guidlines the substance is minimally irritating.
- Other effects:
- There was no indication of pain during dosing.
Applicant's summary and conclusion
- Conclusions:
- Data are not sufficient for a final interpretation.
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