Registration Dossier
Registration Dossier
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EC number: 500-105-6 | CAS number: 39423-51-3 1 - 6.5 moles propoxylated
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010-10-08 to 2010-10-13
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Test material form:
- liquid
- Details on test material:
- Name of test material: Trimethylolpropanepoly(oxypropylene)triamine
EC no.: 500-105-6
CAS no.: 39423-51-3
Physical state: clear colourless liquid
Constituent 1
- Specific details on test material used for the study:
- Polyoxypropylene triamine
(39423-51-3) 60-100% - Radiolabelling:
- no
Study design
- Analytical monitoring:
- yes
- Details on sampling:
- Sampling at 0, 2.4 and 120 hours
- Buffers:
- pH 5: 18.06 g of potassium di-hydrogen phosphate (MW 136.09) and 0.152 g of di-sodium hydrogen phosphate (MW 142.0) made up to 2 litres with deionised water
pH 7: 290 ml of 1.0 M sodium hydroxide and 68.0 g of potassium di-hydrogen phosphate (MW 136.09) made up to 10 litres with deionised water
pH 9: 46 ml 1.0 M sodium hydroxide and 47.8 g borax (Na2B4O7.10H2O, MW 381.37) made up to 10 litres with deionised water - Details on test conditions:
- 50 °C in a water bath
- Number of replicates:
- Three per pH
- Positive controls:
- no
- Negative controls:
- no
Results and discussion
- Preliminary study:
- pH 6* = 2.43% after 5 days at 50 °C
pH 7 = 3.03% after 5 days at 50 °C
pH 9 = 2.90% after 5 days at 50 °C
*The pH 5 stock solution was elevated to pH 6 after the addition of the test substance - Test performance:
- The test substance is hydrolytically stable
- Transformation products:
- no
Dissipation DT50 of parent compound
- Remarks on result:
- hydrolytically stable based on preliminary test
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test substance is demonstrated to be hydrolytically stable
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