Registration Dossier

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2010-10-08 to 2010-10-13
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Deviations:
no
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
Name of test material: Trimethylolpropanepoly(oxypropylene)triamine
EC no.: 500-105-6
CAS no.: 39423-51-3
Physical state: clear colourless liquid
Specific details on test material used for the study:
Polyoxypropylene triamine
(39423-51-3) 60-100%
Radiolabelling:
no

Study design

Analytical monitoring:
yes
Details on sampling:
Sampling at 0, 2.4 and 120 hours
Buffers:
pH 5: 18.06 g of potassium di-hydrogen phosphate (MW 136.09) and 0.152 g of di-sodium hydrogen phosphate (MW 142.0) made up to 2 litres with deionised water
pH 7: 290 ml of 1.0 M sodium hydroxide and 68.0 g of potassium di-hydrogen phosphate (MW 136.09) made up to 10 litres with deionised water
pH 9: 46 ml 1.0 M sodium hydroxide and 47.8 g borax (Na2B4O7.10H2O, MW 381.37) made up to 10 litres with deionised water
Details on test conditions:
50 °C in a water bath
Number of replicates:
Three per pH
Positive controls:
no
Negative controls:
no

Results and discussion

Preliminary study:
pH 6* = 2.43% after 5 days at 50 °C
pH 7 = 3.03% after 5 days at 50 °C
pH 9 = 2.90% after 5 days at 50 °C

*The pH 5 stock solution was elevated to pH 6 after the addition of the test substance
Test performance:
The test substance is hydrolytically stable
Transformation products:
no
Dissipation DT50 of parent compound
Remarks on result:
hydrolytically stable based on preliminary test

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The test substance is demonstrated to be hydrolytically stable