Registration Dossier
Registration Dossier
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EC number: 940-411-0 | CAS number: 1353749-74-2
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The scientific validity of the (Q)SAR model has been established in accordance with the OECD Principles for (Q)SAR Model Validation.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 014
Materials and methods
- Principles of method if other than guideline:
- Times v.2.27.13 in QSAR Toolbox 3.2.0.103
Toolbox prediction report is attached in IUCLID. - GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-amino-3-hydroxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]propanehydrazide hydrochloride
- EC Number:
- 940-411-0
- Cas Number:
- 1353749-74-2
- Molecular formula:
- C10H14ClN3O5
- IUPAC Name:
- 2-amino-3-hydroxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]propanehydrazide hydrochloride
- Details on test material:
- SMILES:OCC(C(=O)NN=Cc1ccc(O)c(O)c1O)N{+}.Cl{-}
Constituent 1
Results and discussion
Test results
- Genotoxicity:
- positive
Any other information on results incl. tables
Estimation method: SAR/(Q)SAR prediction
OUT OF DOMAIN
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): positive
The prediction is positive. - Executive summary:
The Times model for in vivo micronucleus formation was used within the QSAR Toolbox. The prediction was positive. Additional supporting documentation is provided in the prediction report attached in IUCLID.
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